Identification of MHC Alleles Associated With Disease Resistance/Susceptibility In Smallholder Cattle In Zambia
Keywords:
Major Histocompatibility complex; Bovine leukaemia virus (BLV); Foot and Mouth disease; Mastitis; Theileriosis
Abstract
Background: The occurrence of Major Histocompatibility complex (MHC) alleles associated with disease resistance/susceptibility in African cattle is ill-defined. Methods: Herein, we used manual annotation to identify animals possessing MHC alleles associated with disease resistance/susceptibility from a database of alleles sequenced from 846 cattle in Zambia. Results: Overall, we found 28 (3.3%), 21 (2.6%), 55 (6.5%), and 15 (1.8%) animals with resistance alleles to Mastitis, BLV, Theileriosis, FMD, and 39 (4.6%) animals susceptibility alleles to Dermatophilosis, respectively. Conclusion: This study provides the first evidence of resistance/susceptibility alleles in smallholder cattle in Zambia and the data could aid strategies for breeding cattle with enhanced resistance to disease in endemic countries.References
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3. Food and Agriculture Organization of the United Nations,. Economic analysis of animal diseases. Animal Production and Health Guidelines. No. 18. 2016; Rome Italy.
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5. Vasoya D, Law A, Motta P, Yu M, Muwonge A, Cook E, et al., Rapid identification of bovine MHCI haplotypes in genetically divergent cattle populations using next-generation sequencing, Immunogenetics. 2016; 68:765–781
6. Kulberg S, Heringstad B, Guttersrud O, Olsaker I,. Study on the association of BoLA-DRB3.2 alleles with clinical mastitis in Norwegian Red cows. Journal of Animal Breeding and Genetics 2007; 124 (4) 201–207.
7. Xu A, van Eijk MJ, Park C, and Lewin HA,. Polymorphism in BoLA‐DRB3 exon 2 correlates with resistance to persistent lymphocytosis caused by bovine leukaemia virus. Journal of Immunology 1993; 6977‐85.
8. Baxter R, Craigmile SC, Haley C, Douglas AJ, Williams JL, and Glass EJ,. BoLA-DR peptide binding pockets are fundamental for foot-and-mouth disease virus vaccine design in cattle. Vaccine 2009; 28, 28–37.
9. Ballingall K, Luyai A, Rowlands S J, Musoke A, Morzaria S, and Mckeever D,. Bovine Leukocyte Antigen Major Histocompatibility Complex Class II DRB3*2703 and DRB3*1501 Alleles Are Associated with Variation in Levels of Protection against Theileria parva Challenge following Immunization with the Sporozoite p67 Antigen. Infection and immunity. 2004; 72. 2738-41.
10. Maillard JC, Chantal I, Berthier D, Stachurski F, and Elsen JM,. Molecular markers of genetic resistance and susceptibility to bovine dermatophilosis. Archives of Animal Breeding 1999; 42 93–96.
11. Samui KL and Hugh-Jones ME,. The prevalence of bovine dermatophilosis in zambia proceedings of the 5th International Symposium on Veterinary Epidemiology and Economics. Acta Veterinaria Scandinavia, 1988; Supplementum 84.
12. Phiri MM, Kaimoyo E, Changula K, Silwamba I, Chambaro HM, Kapila P, et al., Molecular detection and characterization of genotype 1 bovine leukemia virus from beef cattle in the traditional sector in Zambia. Archives of virology 2019; 04350-6
13. Nambota A, Samui K, Sugimoto C, Kakuta T, and Onuma M,. Theileriosis in Zambia. Aetiology, epidemiology and control measures. Japanese journal of veterinary research 1994; 42.1.1
14. Whitworth KM, Rowland RR, Petrovan V,. Resistance to coronavirus infection in amino peptidase N-deficient pigs. Transgenic Research; 2018; DOI: 10.1007/s11248-018-0100-3
15. World organisation for animal health,. Listed diseases, infections and infestations in force. 2019; https://www.oie.int/animal-health-in-the-world/oie-listed-diseases.
16. Food and Agriculture Organization of the United Nations,. Impact of mastitis in small scale dairy production systems. Animal Production and Health Working Paper. 2014; No. 13. Rome Italy.
17. Samui KL and Hugh-Jones ME,. The financial and production impacts of bovine dermatophilosis in Zambia. Veterinary Research Communications. 1990; (14) 357.
Published
2021-05-11
How to Cite
1.
Silwamba I, Simuunza M, Nalubamba K, Ndebe J, Simulundu E, Mainda G, Muma J. Identification of MHC Alleles Associated With Disease Resistance/Susceptibility In Smallholder Cattle In Zambia. Journal of Agricultural and Biomedical Sciences [Internet]. 11May2021 [cited 22Nov.2024];5(1). Available from: https://engineering.unza.zm/index.php/JABS/article/view/494
Section
Veterinary Medicine
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